LDL-C/HDL-C Ratio and Carotid Intima-Media Thickness Progression
Author Information
Author(s): Enomoto Mika, Adachi Hisashi, Hirai Yuji, Fukami Ako, Satoh Akira, Otsuka Maki, Kumagae Shun-Ichi, Nanjo Yasuki, Yoshikawa Kuniko, Esaki Eishi, Kumagai Eita, Ogata Kinuka, Kasahara Akiko, Tsukagawa Eri, Yokoi Kanako, Ohbu-Murayama Kyoko, Imaizumi Tsutomu
Primary Institution: Kurume University School of Medicine
Hypothesis
Is the LDL-C/HDL-C ratio a better predictor of carotid intima-media thickness progression than HDL-C or LDL-C alone?
Conclusion
The LDL-C/HDL-C ratio is a better predictor of carotid intima-media thickness progression than HDL-C or LDL-C alone.
Supporting Evidence
- Changes in IMT were significantly related to HDL-C and LDL-C/HDL-C ratio.
- LDL-C/HDL-C ratio was a stronger predictor of IMT progression than individual cholesterol levels.
- Follow-up rate was 75.8% with complete data sets available from 1,456 subjects.
Takeaway
This study found that the ratio of bad cholesterol to good cholesterol can help predict heart problems better than looking at each type of cholesterol by itself.
Methodology
The study measured changes in carotid intima-media thickness in 1,920 subjects over 8 years using ultrasonography.
Potential Biases
Potential bias due to missing data from subjects who could not be followed up.
Limitations
The study lacked biochemical measurements and medication data at follow-up, did not measure total plaque area, and only included subjects over 40 years old.
Participant Demographics
794 men and 1,126 women, all over the age of 40.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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