Medication Non-Persistence in Older Patients with Peripheral Arterial Disease
Author Information
Author(s): Wawruch Martin, Petrova Miriam, Celovska Denisa, Alfian Sofa D., Tesar Tomas, Murin Jan, Trnka Michal, Paduch Tomas, Aarnio Emma
Primary Institution: Institute of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Comenius University, Bratislava, Slovakia
Hypothesis
What factors are associated with non-persistence in older hypertensive patients with peripheral arterial disease taking multiple medications?
Conclusion
Over half of older hypertensive patients with peripheral arterial disease became non-persistent with at least one medication class during the study period.
Supporting Evidence
- 55% of patients were classified as non-persistent with at least one medication class.
- Female patients showed a higher rate of non-persistence compared to males.
- Factors associated with non-persistence included female sex and being a new user of medications.
Takeaway
Many older patients with leg artery problems don't stick to their medicine, especially women. It's important to help them take their meds regularly.
Methodology
A cohort study analyzing 3,401 hypertensive patients aged 65 and older, focusing on their persistence with statins, antiplatelet agents, and ACEIs/ARBs.
Potential Biases
Potential biases due to reliance on insurance data for medication adherence without direct patient feedback.
Limitations
The study relied on insurance data, which may not capture all reasons for medication discontinuation or the severity of peripheral arterial disease.
Participant Demographics
Patients aged 65 and older, with 1,853 females and 1,548 males.
Statistical Information
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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