Diversity of Raft-Like Domains in Late Endosomes
2007
Diversity of Raft-Like Domains in Late Endosomes
publication
Evidence: moderate
Author Information
Author(s): Sobo Komla, Chevallier Julien, Parton Robert G., Gruenberg Jean, van der Goot F. Gisou
Primary Institution: University of Geneva
Hypothesis
Are late endosomal membranes sub-compartmentalized into membrane microdomains?
Conclusion
Late endosomes contain cholesterol-rich microdomains that differ in composition and properties.
Supporting Evidence
- Late endosomes contain raft-type membrane domains.
- These domains vary in protein composition and properties.
- Cholesterol-rich microdomains are present on both the limiting membrane and intraluminal vesicles.
Takeaway
Late endosomes, which help transport materials in cells, have special areas rich in cholesterol that help them work better.
Methodology
Sub-organellar fractionation techniques combined with electron microscopy were used to analyze late endosomal membranes.
Digital Object Identifier (DOI)
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