Efficacy of Antimycotic Drugs in Nigeria
Author Information
Author(s): Ogunshe Adenike A. O., Adepoju Adedayo A., Oladimeji Modupe E.
Primary Institution: University of Ibadan, Nigeria
Hypothesis
This study aimed at evaluating the in vitro efficacy and health implications of inconsistencies in different production batches of antimycotic drugs.
Conclusion
Candida strains exhibited different in vitro susceptibility/resistance patterns toward two batches of corresponding antimycotic agents, which has clinical implications on the efficacy of the drugs and treatment of patients.
Supporting Evidence
- None of the Candida strains had entirely the same susceptibility profiles in both batches.
- Up to 57.1% of C. albicans strains were susceptible in one batch but resistant in the other.
- Only 14.3% of C. albicans had similar susceptibility/resistance profiles in both batches.
- Varying multiple antifungal susceptibility rates were recorded in batches 1 and 2.
Takeaway
The study found that different batches of antifungal drugs can work differently on the same type of yeast, which is important for treating infections.
Methodology
In vitro susceptibility profiles of Candida spp. were determined using modified agar well-diffusion method.
Limitations
The study was limited to specific strains of Candida and may not represent all strains or conditions.
Participant Demographics
Participants were patients presenting for candidosis who had not been on antimycotic therapy for about 6 months prior to sample collection.
Statistical Information
P-Value
0.016646
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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