Reduced expression of intercellular adhesion molecule-1 in ovarian adenocarcinomas
2001
Reduced ICAM-1 Expression in Ovarian Cancer
publication
Evidence: moderate
Author Information
Author(s): Arnold J M, Cummings M, Purdie D, Chenevix-Trench G
Primary Institution: The Queensland Institute of Medical Research
Hypothesis
The study investigates the expression levels of intercellular adhesion molecule-1 (ICAM-1) in ovarian adenocarcinomas.
Conclusion
Lower levels of ICAM-1 expression in ovarian tumors may be linked to patient survival.
Supporting Evidence
- ICAM-1 was expressed at lower levels in ovarian tumor cell lines compared to normal ovarian cells.
- Methylation of CpG islands may contribute to the reduced expression of ICAM-1 in tumors.
- A significant association was found between ICAM-1 expression and patient survival.
Takeaway
This study found that a protein called ICAM-1 is less present in ovarian cancer cells, and this might affect how long patients live.
Methodology
Gene expression was analyzed using a cDNA array containing 588 known human genes.
Statistical Information
P-Value
0.03
Statistical Significance
p=0.03
Digital Object Identifier (DOI)
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