How Lactiplantibacillus plantarum HY7714 Helps Skin and Gut Health
Author Information
Author(s): Lee Hayera, Lee Yun-Ha, Hong Dong-Ki, Mo Sung-Jun, Jeon Soomin, Park Soo-Dong, Shim Jae-Jung, Lee Jeong-Lyoul, Lee Jae-Hwan, Baik Sang-Ho
Primary Institution: R&BD Center, hy Co., Ltd.
Hypothesis
The study hypothesized that extracellular vesicles secreted by Lactiplantibacillus plantarum HY7714 would improve both intestinal health and skin aging.
Conclusion
HY7714-derived extracellular vesicles enhance both intestinal and skin health by reducing inflammation and improving barrier function.
Supporting Evidence
- HY7714 EVs improved intestinal cell structure and barrier function.
- HY7714 EVs reduced inflammatory cytokines in intestinal cells.
- HY7714 EVs decreased cytotoxicity in skin cells exposed to UVB radiation.
- RNA sequencing showed downregulation of proteins linked to inflammation and skin health.
Takeaway
This study found that tiny particles from a type of good bacteria can help keep our gut and skin healthy by fighting inflammation.
Methodology
The study used gut-on-a-chip technology and in vitro models to analyze the effects of HY7714-derived extracellular vesicles on intestinal inflammation and skin aging.
Potential Biases
The authors were employed by the company that conducted the research, which may introduce bias.
Limitations
The study did not fully elucidate all mechanisms related to the protective effect of HY7714 EVs on the intestines and requires further clinical studies.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website