Effects of a Japanese Herbal Medicine on Airway Inflammation in Mice
Author Information
Author(s): Nagai Takayuki, Nakao Marino, Shimizu Yuliko, Kodera Yoshio, Oh-Ishi Masamichi, Maeda Tadakazu, Yamada Haruki
Primary Institution: Kitasato University, Tokyo, Japan
Hypothesis
What is the action mechanism of the Kampo medicine Shoseiryuto on bronchial asthma in a mouse model?
Conclusion
The Kampo medicine Shoseiryuto reduces airway inflammation and eosinophil counts in a mouse model of allergic asthma.
Supporting Evidence
- Shoseiryuto reduced inflammation in lung tissue and the number of eosinophils in a mouse model.
- Administration of Shoseiryuto decreased allergen-specific IgE antibody levels in plasma and BAL fluid.
- Shoseiryuto improved airway hyperreactivity in the mouse model of asthma.
- Prednisolone did not recover the expression of spectrin α2 in lung tissue, unlike Shoseiryuto.
Takeaway
A Japanese herbal medicine called Shoseiryuto helps reduce inflammation and allergy symptoms in mice with asthma.
Methodology
Mice were sensitized with ovalbumin and treated with Shoseiryuto or prednisolone, followed by analysis of inflammation and eosinophil counts.
Limitations
The study was conducted only in a mouse model, which may not fully represent human asthma.
Participant Demographics
Five-week-old female BALB/c mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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