High MBL Genotypes Linked to Rheumatoid Arthritis in Never Smokers
Author Information
Author(s): Saevarsdottir Saedis, Ding Bo, Steinsson Kristjan, Grondal Gerdur, Valdimarsson Helgi, Alfredsson Lars, Klareskog Lars, Padyukov Leonid
Primary Institution: Karolinska University Hospital
Hypothesis
Do high mannan-binding lectin (MBL) genotypes predispose to rheumatoid arthritis (RA) in never smokers?
Conclusion
High MBL levels may increase the risk of rheumatoid factor-negative RA, but only in individuals who have never smoked.
Supporting Evidence
- The study found that MBL-high genotypes were associated with RF-negative RA in never smokers.
- In never smokers, the association was significant for both RF-negative/ACPA-negative and RF-negative/ACPA-positive subgroups.
- The findings were replicated in extended RA families, confirming the association in never smokers.
Takeaway
People who have never smoked and have high levels of a protein called MBL might be more likely to get a type of arthritis that doesn't show certain antibodies.
Methodology
The study used a population-based case-control design, analyzing MBL genotypes in RA cases and matched controls, with logistic regression to calculate odds ratios.
Potential Biases
Potential bias due to self-reported smoking status and the inability to account for all environmental factors.
Limitations
The study's findings may not apply to smokers, and the analysis was limited to certain genetic and environmental factors.
Participant Demographics
70% of the RA patients were female, median age was 54 years.
Statistical Information
P-Value
0.0005
Confidence Interval
95% CI 1.24-2.69
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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