Economic evaluation of a clinical protocol for diagnosing emergency patients with suspected pulmonary embolism
2006

Cost Savings from a New Protocol for Diagnosing Pulmonary Embolism

Sample size: 930 publication 10 minutes Evidence: high

Author Information

Author(s): Gospodarevskaya Elena V, Goergen Stacy K, Harris Anthony H, Chan Thomas, de Campo John F, Wolfe Rory, Gan Eng T, Wheeler Michael B, McKay John

Primary Institution: Centre for Health Economics, Monash University, Australia

Hypothesis

Implementing an evidence-based clinical protocol will not change the number of correctly diagnosed pulmonary embolism patients but will save resources.

Conclusion

The study found that using a new clinical protocol for diagnosing pulmonary embolism can save the Australian healthcare system between $3.1 million to $3.7 million annually.

Supporting Evidence

  • The new protocol reduced the use of diagnostic imaging tests without increasing the risk of misdiagnosing pulmonary embolism.
  • Cost savings were primarily due to a reduction in the number of pulmonary vascular imaging tests for low-risk patients.
  • The negative predictive value of the new protocol was found to be 99%.
  • Implementation of the protocol involved training sessions for emergency department staff.
  • The study included a total of 930 patients across both control and intervention groups.
  • Annual cost savings for the healthcare system were estimated between $3.1 million to $3.7 million.
  • Patients categorized as low risk and with negative D-dimer results had a very low incidence of pulmonary embolism.
  • The study demonstrated that the new protocol is as effective as existing practices.

Takeaway

Doctors can use a simple test to check for a serious lung problem called pulmonary embolism, which saves money and helps patients without putting them at risk.

Methodology

A cost-minimisation study comparing diagnostic tests in a historical cohort and an intervention group using a new clinical protocol.

Potential Biases

Potential bias due to the non-randomized design and reliance on historical controls.

Limitations

The study used a non-random historic control group, which may introduce bias.

Participant Demographics

The control group had 185 patients with a mean age of 56.2 years, while the intervention group had 745 patients with a mean age of 55.0 years.

Statistical Information

P-Value

0.002

Confidence Interval

95% CI = 96% – 100%

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/1478-7547-4-12

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