Organic Papers
2011
(2Z,3E)-2-{[1-(4-Chlorobenzyl)-1H-indol-3-yl]methylidene}quinuclidin-3-one oxime
publication
Evidence: moderate
Author Information
Author(s): Penthala Narsimha Reddy, Reddy Thirupathi Reddy Yerram, Parkin Sean, Crooks Peter A.
Primary Institution: University of Kentucky
Hypothesis
The study aims to synthesize and analyze the structure of a new compound related to radio-sensitization activity.
Conclusion
X-ray crystallography confirmed the molecular structure and atom connectivity of the synthesized compound.
Supporting Evidence
- The benzene ring of the 4-chlorobenzyl group makes a dihedral angle of 78.56° with the indole ring.
- The double bond connecting the azabicyclic and indole groups adopts a Z geometry.
- The absolute configuration of the compound was determined from refinement of the Flack parameter.
Takeaway
The researchers made a new chemical compound and used X-ray to see what it looks like and how its atoms are connected.
Methodology
The compound was synthesized through aldol condensation and analyzed using X-ray crystallography.
Digital Object Identifier (DOI)
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