Impact of Chorionicity in Neurodevelopmental Outcomes in Preterm Twins
Author Information
Author(s): Muacevic Alexander, Adler John R, Leuzinger Dias Catarina, Cordeiro Catarina, Camacho-Sampaio Margarida, Lomba Andreia, Taborda Adelaide
Primary Institution: Maternidade Bissaya Barreto, Unidade Local de Saúde de Coimbra, Coimbra, PRT
Hypothesis
Chorionicity does not influence neurodevelopmental impairment in preterm twins.
Conclusion
Chorionicity alone does not appear to independently affect neurodevelopmental outcomes in preterm twins when complications are effectively managed.
Supporting Evidence
- 5.6% of the infants had moderate to severe neurodevelopmental impairment.
- Gestational age over 27 weeks and birth weight over 1010 grams were identified as accurate predictors for an absence of moderate to severe NDI.
- 29% of infants with moderate to severe NDI were monochorionic twins.
Takeaway
This study looked at twins born early and found that whether they shared a placenta or not didn't change their chances of having development problems, as long as they got good care.
Methodology
A retrospective cohort study including preterm twins born before 32 weeks of gestational age and/or with a birth weight of less than 1500 grams, evaluated at 24 months of corrected age using the Griffiths II Mental Development Scales.
Potential Biases
Memory and registration biases are minimized due to systematic data recording.
Limitations
The study's retrospective nature and small sample size may affect the quality of the analysis.
Participant Demographics
Preterm twins born before 32 weeks of gestational age and/or with a birth weight of less than 1500 grams.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI 0.58-0.93
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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