Long-term effects of STN DBS on mood in Parkinson's patients
Author Information
Author(s): Kaiser Iris, Kryspin-Exner Ilse, Brücke Thomas, Volc Dieter, Alesch François
Primary Institution: Medical University of Vienna
Hypothesis
What are the long-term effects of subthalamic nucleus deep brain stimulation on mood and psychosocial functions in patients with Parkinson's disease?
Conclusion
No worsening in mood and psychosocial functions was found three years after STN DBS.
Supporting Evidence
- Motor function significantly improved after surgery.
- Mood and psychosocial functions improved at one year but returned to baseline at three years.
- Patients can be assigned to four distinct psychosocial profiles that remained stable over time.
- Patients with mild psychiatric disturbances should not be excluded from surgery.
Takeaway
Doctors used a special treatment to help people with Parkinson's disease, and they found that while some feelings got better for a little while, they went back to normal after three years.
Methodology
Self-rating questionnaires were administered to patients before and after surgery at multiple time points.
Potential Biases
Potential bias due to the self-reported nature of the questionnaires.
Limitations
The study had a small sample size and some patients dropped out over time.
Participant Demographics
33 patients (22 men, 11 women) with advanced Parkinson's disease.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website