Study of Shigella sonnei in Tehran, Iran
Author Information
Author(s): Ranjbar Reza, Aleo Aurora, Giammanco Giovanni M, Dionisi Anna Maria, Sadeghifard Nourkhoda, Mammina Caterina
Primary Institution: Research Center of Molecular Biology, Baqiyatallah University of Medical Sciences, Tehran, Iran
Hypothesis
What are the phenotypic and genetic characteristics of Shigella sonnei isolates in Tehran, Iran during 2002-2003?
Conclusion
Biotype g, class 2 integron carrying S. sonnei are prevalent in Tehran, with a few predominant clusters responsible for shigellosis.
Supporting Evidence
- 54 of the 57 recent isolates exhibited biotype g and resistance to multiple antibiotics.
- Class 2 integrons were found in 28 isolates with a 2161 bp structure and 24 isolates with a 1371 bp structure.
- PFGE analysis divided the strains into eight pulsotypes, with A and C being the most prevalent.
Takeaway
The study found that a type of bacteria called Shigella sonnei is common in Tehran and has some specific genetic traits that make it resistant to certain medicines.
Methodology
The study involved biotyping, drug susceptibility testing, PFGE, and analysis of class 2 integrons on 60 S. sonnei isolates.
Limitations
The study only included isolates from Tehran and may not represent the entire country.
Participant Demographics
Isolates were from pediatric cases of shigellosis in Tehran.
Digital Object Identifier (DOI)
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