Ellagic Acid Enhances Fluconazole's Effect Against Candida albicans
Author Information
Author(s): Mendes Amanda Graziela Gonçalves, Campos Carmem Duarte Lima, Pereira-Filho José Lima, Pereira Aleania Polassa Almeida, Reis Gabriel Silva Abrantes, Araújo Árlon Wendel de Marinho Silva, Monteiro Pablo de Matos, Vidal Flávia Castello Branco, Monteiro Silvio Gomes, da Silva Figueiredo Isabella Fernandes, Fernandes Elizabeth Soares, Monteiro Cristina de Andrade, Monteiro-Neto Valério, DellaGreca Marina
Primary Institution: Centro de Ciências da Saúde, Universidade Federal do Maranhão
Hypothesis
Does ellagic acid enhance the antifungal effects of fluconazole against Candida albicans?
Conclusion
Ellagic acid can significantly enhance the antifungal effects of fluconazole against Candida albicans, suggesting its potential as a treatment adjuvant.
Supporting Evidence
- Ellagic acid showed antifungal activity against all tested Candida albicans isolates.
- Ellagic acid reduced the Minimum Inhibitory Concentration of fluconazole by up to 32-fold.
- Ellagic acid did not exhibit hemolytic activity and showed low cytotoxicity in HeLa cells.
Takeaway
This study found that a natural compound called ellagic acid can help a common antifungal medicine work better against a type of yeast that can make people sick.
Methodology
The study used broth microdilution to determine the Minimum Inhibitory Concentration (MIC) of ellagic acid and fluconazole, and assessed their interactions using a checkerboard assay.
Limitations
The study did not evaluate the activity of ellagic acid against other species of Candida and lacked in vivo testing.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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