Reproducibility of 4D CT Scans for Lung Cancer Treatment
Author Information
Author(s): Ylanga G van der Geld, Frank J Lagerwaard, John R van Sörnsen de Koste, Johan P Cuijpers, Ben J Slotman, Suresh Senan
Primary Institution: VU University medical center, Amsterdam, The Netherlands
Hypothesis
The study aims to evaluate the reproducibility of target volumes generated during repeat uncoached 4D CT scans for patients with peripheral lung cancer.
Conclusion
In nearly all patients with stage I lung cancer, the PTV derived from a single uncoached 4DCT achieves dosimetric coverage that is similar to that achieved using two such consecutive scans.
Supporting Evidence
- No significant volumetric differences were observed between the two PTVs.
- The average displacement of the center of mass between corresponding PTVs was 1.4 ± 1.0 mm.
- Coverage of both PTVs by the 80% prescription isodose exceeded 90% for all but one patient.
Takeaway
Doctors used special scans to see how well they can target lung tumors during treatment, and they found that one scan is often just as good as two.
Methodology
A retrospective analysis of two successive 4D CT scans for 26 patients with peripheral lung cancer was performed, comparing the volumes and positions of planning target volumes.
Limitations
The study is limited to patients with stage I lung cancer and may not apply to other stages or types of lung cancer.
Participant Demographics
Patients with stage I non-small cell lung cancer treated with stereotactic radiotherapy.
Statistical Information
P-Value
0.60
Statistical Significance
p = 0.60
Digital Object Identifier (DOI)
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