Flavone Acetic Acid Trials in Cancer
Author Information
Author(s): D.J. Kerr, T. Maughan, E. Newlands, G. Rustin, N.M. Bleehen, C. Lewis, S.B. Kaye
Primary Institution: University of Glasgow
Hypothesis
Does flavone acetic acid (FAA) have clinical activity in advanced malignant melanoma and colorectal carcinoma?
Conclusion
Flavone acetic acid has no demonstrable clinical activity in advanced malignant melanoma and colorectal carcinoma.
Supporting Evidence
- Overall, the toxicity was mild, but two patients were withdrawn due to severe side effects.
- Thirteen melanoma patients progressed on treatment, and one had stable disease.
- Nine evaluable colorectal patients progressed on treatment, and six had stable disease.
Takeaway
The study tested a drug called flavone acetic acid on cancer patients, but it didn't help them get better.
Methodology
Patients with advanced melanoma and colorectal carcinoma received flavone acetic acid via a 6-hour infusion for 6 weeks.
Limitations
The study had a small sample size and no patients showed a positive response to the treatment.
Participant Demographics
{"colorectal_cancer":{"male_female_ratio":"10/5","median_age":51,"age_range":"42-71"},"melanoma":{"male_female_ratio":"5/9","median_age":48,"age_range":"28-69"}}
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