Mitral Valve Repair in Dogs Using the Canine V-Clamp Device
Author Information
Author(s): Potter Brianna M., Orton E. Christopher, Scansen Brian A., Abbott-Johnson Katie M., Visser Lance C., Chi I-Jung B., Ross Evan S., Del Nero Bruna, Tantisuwat Lalida, Krause Ellen T., Rezende Marlis L., Mama Khursheed
Primary Institution: Colorado State University
Hypothesis
To determine procedural feasibility, safety, and short-term efficacy in dogs with severe degenerative mitral regurgitation undergoing transcatheter edge-to-edge repair with a canine-specific device.
Conclusion
Initial feasibility results support continued development of TEER as a procedurally feasible, relatively low-risk, and low morbidity treatment for degenerative MR in dogs.
Supporting Evidence
- Procedural feasibility was 96% based on delivery of at least one device in 48 of 50 dogs.
- There were no procedural deaths.
- Device-related adverse event rate was 6.3% based on 3 events in 59 implanted devices.
- Median regurgitant volume decreased from 2.3 to 1.1 mL/kg.
- Median effective regurgitant orifice area decreased from 0.60 to 0.25 cm2/m2.
Takeaway
This study tested a new way to fix heart valves in dogs, and it worked well for most of the dogs involved.
Methodology
A prospective, single-arm clinical feasibility study using transcatheter edge-to-edge repair with the Canine Mitral V-Clamp device.
Potential Biases
Operator inexperience and inappropriate case selection contributed to procedural failures.
Limitations
The study was uncontrolled and only reports short-term efficacy.
Participant Demographics
Fifty client-owned dogs with severe degenerative mitral regurgitation, median age 9.9 years, 26% female.
Statistical Information
P-Value
p<0.001
Confidence Interval
[1.9, 3.1] to [0.3, 1.8]
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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