Prognostic Factors for Esophageal Squamous Cell Carcinoma in Golestan, Iran
Author Information
Author(s): Aghcheli Karim, Marjani Haji-Amin, Nasrollahzadeh Dariush, Islami Farhad, Shakeri Ramin, Sotoudeh Masoud, Abedi-Ardekani Behnoush, Ghavamnasiri Mohammad-Reza, Razaei Ezzatollah, Khalilipour Elias, Mohtashami Samira, Makhdoomi Yasha, Rajabzadeh Rabea, Merat Shahin, Sotoudehmanesh Rasoul, Semnani Shahryar, Malekzadeh Reza
Primary Institution: Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Hypothesis
What are the prognostic factors affecting survival in esophageal squamous cell carcinoma (ESCC) cases in Golestan Province, Iran?
Conclusion
The prognosis of esophageal squamous cell carcinoma in Golestan is very poor, with several factors influencing survival.
Supporting Evidence
- Median survival for ESCC cases was found to be 7 months.
- Older age was associated with poorer prognosis, but this association disappeared after adjusting for treatment.
- Urban residents had better prognosis compared to rural residents.
- Nass chewing was associated with poorer prognosis even after adjusting for other factors.
Takeaway
This study looked at people with a type of throat cancer in Iran and found that many things, like age and treatment, can affect how long they live after being diagnosed.
Methodology
The study followed up 426 ESCC cases from a population-based case-control study and analyzed data using Kaplan–Meier and Cox proportional hazard models.
Potential Biases
Potential cultural differences in treatment consent and access to medical facilities may introduce bias.
Limitations
Staging data were not available for many participants, and socioeconomic status indicators were only available for less than half of participants.
Participant Demographics
Participants were diagnosed with ESCC in Golestan Province, Iran, with a mix of urban and rural residents.
Statistical Information
P-Value
p<0.0001
Confidence Interval
95% CI 0.54–0.90 for urban residence; 95% CI 0.61–0.96 for non-Turkmen ethnicity; 95% CI 0.99–1.92 for nass chewing.
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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