COX-2 and PPARγ in Ovarian Tumours
Author Information
Author(s): Sakamoto A, Yokoyama Y, Umemoto M, Futagami M, Sakamoto T, Bing X, Mizunuma H
Primary Institution: Hirosaki University School of Medicine
Hypothesis
Is the expression of COX-2 and PPARγ associated with ovarian carcinogenesis and progression of ovarian tumours?
Conclusion
The study found that high COX-2 expression and low PPARγ expression may contribute to the progression of ovarian tumours to carcinoma.
Supporting Evidence
- COX-2 expression was significantly higher in carcinomas compared to benign tumours.
- PPARγ expression was significantly higher in borderline tumours compared to benign tumours and carcinomas.
- COX-2 and PPARγ positivity in carcinomas was not correlated with clinical factors such as stage or histological type.
Takeaway
This study looked at how two proteins, COX-2 and PPARγ, behave in ovarian tumours, finding that one increases and the other decreases as the tumours become more serious.
Methodology
Immunohistochemical examination of 112 epithelial ovarian tumours was performed retrospectively.
Limitations
The study was retrospective and did not include patients who had received preoperative chemotherapy.
Participant Demographics
Women who were surgically treated for ovarian tumours at Hirosaki University Hospital between 1989 and 2003.
Statistical Information
P-Value
p<0.02, p=0.058, p<0.0001, p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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