Osteoprotegerin and coronary artery disease in type 2 diabetic patients with microalbuminuria
Author Information
Author(s): Reinhard Henrik, Nybo Mads, Hansen Peter R, Wiinberg Niels, Kjær Andreas, Petersen Claus L, Winther Kaj, Parving Hans-Henrik, Rasmussen Lars M, Rossing Peter, Jacobsen Peter K
Primary Institution: Steno Diabetes Center, Gentofte, Denmark
Hypothesis
We investigated the correlation between P-OPG and coronary artery disease (CAD) in asymptomatic type 2 diabetic patients with microalbuminuria.
Conclusion
Elevated P-OPG is an independent predictor of the presence of CAD in asymptomatic type 2 diabetic patients with microalbuminuria.
Supporting Evidence
- Significant CAD was demonstrated in 70 of the high risk patients.
- Among high risk patients, increased P-OPG was an independent predictor of significant CAD.
- 91% of patients with low P-OPG did not have >70% coronary artery stenosis.
Takeaway
This study found that a substance called P-OPG can help doctors figure out if people with diabetes and kidney issues might have heart problems, even if they don't have symptoms.
Methodology
P-OPG was measured in 200 asymptomatic diabetic patients without known cardiac disease, who were stratified into high and low risk groups based on P-NT-proBNP and coronary calcium score.
Potential Biases
There is a significant selection bias in play between patients who had a CAG performed compared to an unselected group of patients with type 2 diabetes and microalbuminuria.
Limitations
The study had a selection bias as low risk patients were not examined for significant CAD, and the positive predictive value of P-OPG for coronary artery stenosis was low.
Participant Demographics
The study included 200 type 2 diabetic patients with microalbuminuria, of which 76% were male, with a mean age of 59 years.
Statistical Information
P-Value
0.051
Confidence Interval
1.01-19.54
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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