Effects of Aging on Men's Sperm Health
Author Information
Author(s): Andrew J. Wyrobek, Brenda Eskenazi, S. Young, N. Arnheim, I. Tiemann-Boege, E.W. Jabs
Primary Institution: Lawrence Livermore National Laboratory
Hypothesis
Does advancing age affect sperm DNA and fertility in men?
Conclusion
As men age, they may face increased risks of certain genetic defects in their children, although not all risks associated with older women apply.
Supporting Evidence
- Fatherhood among men aged 35–49 has increased by 40%.
- Older fathers may have an increased risk of having children with achondroplasia.
- The study suggests men also have a biological clock affecting fertility.
Takeaway
As men get older, their sperm might not work as well, and they could pass on some genetic problems to their kids.
Methodology
The researchers analyzed sperm samples from men aged 22–80 using flow cytometry and statistical analysis.
Limitations
The findings are preliminary and based on a small number of tests in a small population.
Participant Demographics
Nonsmoking men aged 22–80 in generally good health.
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