ADIPOQ Gene Variants and Obesity in Koreans
Author Information
Author(s): Park Ji Wan, Park Jungyong, Jee Sun Ha
Primary Institution: Hallym University and Yonsei University
Hypothesis
This study aimed to measure the association between the ADIPOQ gene variants and obesity in Koreans.
Conclusion
The ADIPOQ gene variants contribute to susceptibility to obesity in healthy Koreans.
Supporting Evidence
- The G allele of -11377C>G significantly increased the risk for obesity.
- Most haplotypes including the G allele were associated with higher obesity risk.
- The study found a significant association between ADIPOQ gene variants and obesity.
Takeaway
This study found that certain gene variations can make people more likely to become obese.
Methodology
The study used a population-based cross-sectional design and genotyped three SNPs in the ADIPOQ gene.
Potential Biases
Potential interactions with other genes related to obesity susceptibility were not assessed.
Limitations
BMI may not be a sufficient indicator for measuring obesity, and environmental factors were not evaluated.
Participant Demographics
The study population consisted of 73.1% men and 26.9% women, aged 21 to 81 years.
Statistical Information
P-Value
p=0.06
Confidence Interval
95% CI, 1.13-1.94
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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