Effects of Alpinia pricei Extracts on Cancer Cells
Author Information
Author(s): Hseu You-Cheng, Chen Chih-Sheng, Wang Sheng-Yang
Primary Institution: China Medical University
Hypothesis
Can Alpinia pricei extracts induce cell cycle arrest and suppress tumor growth in human squamous carcinoma cells?
Conclusion
Alpinia pricei extracts can effectively induce cell cycle arrest and reduce tumor growth in both in vitro and in vivo models.
Supporting Evidence
- AP extracts decreased the proliferation of KB cells by arresting progression through the G2/M phase of the cell cycle.
- AP extract treatment effectively delayed tumor incidence in nude mice inoculated with KB cells.
- AP extracts induced apoptotic DNA fragmentation in KB cells.
Takeaway
This study shows that a plant extract can help stop cancer cells from growing and can even shrink tumors in mice.
Methodology
The study used both in vitro cell culture and in vivo nude mice models to assess the effects of Alpinia pricei extracts on cancer cell growth and tumor development.
Limitations
The study primarily focused on one type of cancer cell and one animal model, which may limit the generalizability of the findings.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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