Transgenic Cattle Producing Human Lysozyme in Milk
Author Information
Author(s): Yang Bin, Wang Jianwu, Tang Bo, Liu Yufang, Guo Chengdong, Yang Penghua, Yu Tian, Li Rong, Zhao Jianmin, Zhang Lei, Dai Yunping, Li Ning
Primary Institution: State Key Laboratory for Agrobiotechnology, China Agricultural University
Hypothesis
Can transgenic cattle be developed to express recombinant human lysozyme in their milk?
Conclusion
The study successfully produced transgenic cattle that express recombinant human lysozyme in their milk, which has similar nutritional benefits as human milk.
Supporting Evidence
- Four transgenic cattle were identified that expressed recombinant human lysozyme.
- The average expression level of recombinant lysozyme was measured at 25.96 mg/L.
- Milk composition from transgenic and non-transgenic cattle showed no significant differences.
- Purified recombinant human lysozyme exhibited similar properties to natural lysozyme.
Takeaway
Scientists made special cows that can produce a protein found in human milk to help babies stay healthy. This milk is just as good for babies as human milk.
Methodology
The researchers used somatic cell nuclear transfer to create cloned transgenic cattle and measured the levels of recombinant human lysozyme in their milk.
Potential Biases
Potential bias due to the involvement of employees from the biotechnology company in the research.
Limitations
The study focused on only four transgenic cattle, and the expression levels of recombinant lysozyme were lower than in other reported systems.
Participant Demographics
Transgenic cattle were cloned from various cell strains.
Statistical Information
P-Value
p=0.546, 0.678, 0.672, 0.837
Statistical Significance
p>0.05
Digital Object Identifier (DOI)
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