First Report of Sylvatic DENV-2-Associated Dengue Hemorrhagic Fever in West Africa
Author Information
Author(s): Franco Leticia, Palacios Gustavo, Martinez José Antonio, Vázquez Ana, Savji Nazir, De Ory Fernando, Sanchez-Seco María Paz, Martín Dolores, Lipkin W. Ian, Tenorio Antonio
Primary Institution: National Center for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
Hypothesis
Can sylvatic strains of dengue virus cause severe disease in humans?
Conclusion
This study reports the first case of dengue hemorrhagic fever associated with sylvatic DENV-2 in Africa, indicating that sylvatic strains may have greater pathogenic potential than previously thought.
Supporting Evidence
- The patient had severe symptoms including thrombocytopenia and mucosal bleeding.
- DENV-2 was isolated from the patient's blood and sera.
- This case is the first documented instance of DHF caused by sylvatic DENV-2 in Africa.
Takeaway
A young man got very sick from a type of dengue virus that usually affects animals, showing that this virus can be dangerous for people too.
Methodology
The case was diagnosed through clinical evaluation and laboratory tests, including PCR for dengue virus detection.
Limitations
The study is based on a single case report, limiting the generalizability of the findings.
Participant Demographics
A 27-year-old male from Guinea Bissau, living in Spain.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website