Antimicrobial Usage and Antimicrobial Resistance in Commensal Escherichia coli from Broiler Farms: A Farm-Level Analysis in West Java, Indonesia

2024

Antimicrobial Use and Resistance in Broiler Farms in Indonesia

Sample size: 19 publication 10 minutes Evidence: moderate

Author Information

Author(s): Anwar Sani, Sunandar, Rachmawati Annisa, Pertela Gian, Susanti Oli, Rahayu Kanti Puji, Allamanda Puttik, Suandy Imron, Nurbiyanti Nofita, Jahja Elvina J., Purwanto Budi, Velkers Francisca C., Dinar Tagrid, Wagenaar Jaap A., Speksnijder David C.

Primary Institution: Utrecht University

Hypothesis

This study examines the relationship between antimicrobial use (AMU) and antimicrobial resistance (AMR) in broiler farms in Indonesia.

Conclusion

The study highlights the urgent need to reduce antimicrobial use, particularly of critically important antimicrobials, to mitigate antimicrobial resistance on Indonesian broiler farms.

Supporting Evidence

The average antimicrobial use was 12 treatment days per production cycle.
93% of E. coli isolates showed non-wildtype phenotypes for ciprofloxacin.
A significant correlation was found between total farm-level AMU and the number of antimicrobials for which non-wildtype E. coli isolates were found.
High levels of antimicrobial resistance were observed across multiple tested antimicrobials.
Preventive use of antimicrobials accounted for 80% of total use on farms.

Takeaway

Farmers in Indonesia use a lot of antibiotics for their chickens, which can make the bacteria in those chickens resistant to medicine, making it harder to treat infections in both animals and people.

Methodology

Data were collected from 19 farms over multiple production cycles to assess AMU and AMR, with statistical analyses performed to evaluate correlations.