Arabinose Mitigate Metabolic Stress in Inflammaging
2024
Arabinose and Its Effects on Inflammaging
publication
Evidence: moderate
Author Information
Author(s): Brenda Landvoigt Schmitt, Patricia Silva da Pantoja, Brandt D Pence
Primary Institution: University of Memphis
Hypothesis
Does arabinose impact the gene expression of pro-inflammatory cytokines and bioenergetic cell metabolism in the context of inflammaging?
Conclusion
Arabinose improves mitochondrial function and reduces inflammation in cells under stress, suggesting potential benefits for older populations.
Supporting Evidence
- Arabinose downregulated pro-inflammatory cytokines IL-1β, IL-6, and TNF-α.
- Pre-treatment with arabinose improved mitochondrial oxidative phosphorylation under inflammatory stress.
- Arabinose protected cells from increased extracellular acidification rate in the presence of lipopolysaccharide.
Takeaway
Arabinose, a sugar found in fruits and vegetables, can help reduce inflammation in older people and improve how their cells produce energy.
Methodology
U937 cell line was treated with arabinose and lipopolysaccharide, followed by analysis of gene expression and mitochondrial activity.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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