Study of Immune Response in Cattle Infected with Foot-and-Mouth Disease Virus
Author Information
Author(s): Carolina Stenfeldt, Peter MH Heegaard, Anders Stockmarr, Kirsten Tjørnehøj, Graham J Belsham
Primary Institution: National Veterinary Institute, Technical University of Denmark
Hypothesis
The study investigates the acute phase responses to foot-and-mouth disease virus (FMDV) infection in cattle and the implications for the development of persistently infected carriers.
Conclusion
The study concluded that serum amyloid A, haptoglobin, and type 1 interferon can be used as markers of acute infection by FMDV in cattle.
Supporting Evidence
- Serum concentrations of acute phase proteins increased significantly in infected animals.
- HP response was lower in animals that became carriers compared to non-carriers.
- Type 1 IFN bioactivity peaked at the onset of clinical symptoms.
Takeaway
When cattle get sick from foot-and-mouth disease, their bodies produce special proteins that can help us know if they are infected.
Methodology
The study involved three independent experiments with 36 infected cattle and 6 control animals, measuring serum concentrations of acute phase proteins and type 1 interferon.
Limitations
The study was limited by the inability to determine carrier status in one of the experiments due to early termination.
Participant Demographics
4-5 month old mixed-Holstein breed steers.
Statistical Information
P-Value
0.04
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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