Disulfidptosis-related genes in hypertrophic cardiomyopathy
Author Information
Author(s): Fan Huimin, Tan Xin, Xu Shuai, Zeng Yiyao, Zhang Hailong, Shao Tong, Zhao Runze, Zhou Peng, Bo Xiaohong, Fan Jili, Fu Yangjun, Ding Xulong
Primary Institution: The Fourth Affiliated Hospital to Soochow University
Hypothesis
This study investigates the relationship between disulfidptosis and hypertrophic cardiomyopathy (HCM) and aims to identify predictive models and therapeutic targets.
Conclusion
The study identifies disulfidptosis-related genes as potential biomarkers and therapeutic targets for hypertrophic cardiomyopathy.
Supporting Evidence
- The study identified 16 differentially expressed disulfidptosis-related genes in HCM patients.
- Machine learning models were used to predict HCM based on these genes.
- Resveratrol was identified as a potential therapeutic drug targeting the core genes.
Takeaway
This research found that certain genes related to a new type of cell death might help us understand and treat a heart condition called hypertrophic cardiomyopathy.
Methodology
The study used gene expression datasets and machine learning models to develop a predictive model for HCM based on disulfidptosis-related genes.
Limitations
More clinical data on HCM patients are needed to validate the expression levels of DRGs, and additional experiments are required to evaluate the therapeutic effect of resveratrol on HCM.
Participant Demographics
The study included 110 HCM patients and 37 controls.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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