Outcomes of Infective Endocarditis in Finnish Adults
Author Information
Author(s): Heiro Maija, Helenius Hans, Hurme Saija, Savunen Timo, Engblom Erik, Nikoskelainen Jukka, Kotilainen Pirkko
Primary Institution: Turku University Hospital
Hypothesis
What factors predict the outcomes of infective endocarditis in patients treated at a Finnish teaching hospital?
Conclusion
High CRP values on admission significantly predict both short-term and 1-year mortality in infective endocarditis.
Supporting Evidence
- High CRP values on admission were associated with a 2.9-fold increase in in-hospital death risk.
- Age ≥65 years significantly predicted 1-year mortality.
- Neurological complications and heart failure were significant predictors of mortality.
- Mortality was significantly higher in infections of 2 native valves compared to other types.
Takeaway
Doctors studied patients with a heart infection to see what makes them better or worse. They found that high levels of a certain protein in the blood can mean a higher chance of dying from the infection.
Methodology
The study analyzed 326 episodes of infective endocarditis in 303 patients treated at a Finnish teaching hospital from 1980 to 2004, focusing on mortality and need for surgery.
Limitations
The long study period may have introduced changes in diagnostic and therapeutic management of endocarditis.
Participant Demographics
The mean age of participants was 54.4 years, with 234 episodes in men and 92 in women.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI 1.33 to 6.40
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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