Lentinan's Role in Melanoma Treatment
Author Information
Author(s): Lai Xuebin, Chen Yanling, Huang Rongjie, Zhu Fukai, Huang Lanqian, Chen Nan, Li Guipeng, Hou Wenze, Pan Yutian, Alitongbieke Gulimiran
Primary Institution: Engineering Technological Center of Mushroom Industry, Minnan Normal University
Hypothesis
Lentinan regulates the Nur77/Bcl-2 apoptotic pathway to inhibit melanoma growth.
Conclusion
Lentinan inhibits tumor growth and promotes apoptosis by regulating the AKT/Nur77/Bcl-2 pathway in melanoma cells.
Supporting Evidence
- Lentinan significantly inhibited the growth and proliferation of melanoma cells.
- Lentinan decreased the expression levels of proliferation-related molecules in melanoma cells.
- Lentinan promoted the interaction between Nur77 and Bcl-2, inducing apoptosis in melanoma cells.
- Lentinan inhibited AKT phosphorylation in melanoma cells.
Takeaway
Lentinan, a substance from shiitake mushrooms, helps fight melanoma by making cancer cells die and stopping them from growing.
Methodology
A tumor-bearing mouse model was used to assess tumor growth, and cell survival was analyzed using the cell counting kit-8 assay.
Limitations
Future studies with a larger sample size are necessary to validate the findings.
Participant Demographics
Eight-week-old C57BL/6 mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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