Histological, epidemiological and clinical aspects of centroblastic-centrocytic lymphomas subdivided according to the 'working formulation'
1984

Study of Centroblastic-Centrocytic Lymphomas

Sample size: 424 publication Evidence: moderate

Author Information

Author(s): W.M. Molenaar, H. Bartels, J. Koudstaal

Primary Institution: University of Groningen, The Netherlands

Hypothesis

How do different cell groups of centroblastic-centrocytic lymphomas affect survival rates?

Conclusion

The study found that while small cell lymphomas had better survival in the first six years, large cell lymphomas had the worst survival overall.

Supporting Evidence

  • Group S had a better survival rate than group M in the first six years after diagnosis.
  • Group L had the worst survival rates throughout the study.
  • Histological parameters showed significant differences in growth patterns among the groups.

Takeaway

This study looked at different types of lymphomas and found that some types do better than others, especially in the first few years after diagnosis.

Methodology

The study involved analyzing histological samples and clinical data from 424 patients diagnosed with centroblastic-centrocytic lymphomas.

Limitations

The study's findings may not apply to patients treated with modern therapies, as most received treatment before these were developed.

Participant Demographics

The cohort included 187 males and 235 females, with ages ranging from 22 to 89 years.

Statistical Information

P-Value

p<0.01

Statistical Significance

p<0.01

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