The Impact of Soluble Fiber on Cholesterol Levels in Patients on Lipid-Lowering Therapy
Author Information
Author(s): Silvia C Ramos, Francisco A Fonseca, Soraia H Kasmas, Flávio T Moreira, Tatiana Helfenstein, Ney C Borges, Ronilson A Moreno, Vinicius M Rezende, Fernanda C Silva, Maria C Izar
Primary Institution: Federal University of Sao Paulo
Hypothesis
Soluble fiber intake can reduce plant sterols absorption among subjects receiving highly effective lipid-lowering therapy.
Conclusion
The intake of 25 g of fibers added favorable effects, mainly by reducing phytosterolemia, and also improved blood glucose and body weight.
Supporting Evidence
- Fiber intake decreased plasma campesterol and β-sitosterol levels.
- Patients receiving fiber had weight loss and reduced body mass index.
- Blood glucose levels were lower in subjects supplemented with fibers.
Takeaway
Eating fiber can help people on cholesterol-lowering medications feel better and lose weight.
Methodology
A randomized, open-label study with 116 subjects assigned to different treatment groups for 12 weeks.
Limitations
The effects of soluble fiber may be masked by the highly effective treatment used, and the study duration may not capture long-term benefits.
Participant Demographics
Men and women aged 30 to 75 with primary or secondary prevention of coronary heart disease.
Statistical Information
P-Value
p < 0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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