CENP-F Expression and Breast Cancer Risk
Author Information
Author(s): Ueda Shigeto, Kondoh Nobuo, Tsuda Hitoshi, Yamamoto Souhei, Asakawa Hideki, Fukatsu Kazuhiko, Kobayashi Takayuki, Yamamoto Junji, Tamura Katsumi, Ishida Jiro, Abe Yoshiyuki, Yamamoto Mikio, Mochizuki Hidetaka
Primary Institution: National Defense Medical College
Hypothesis
The study aims to identify specific molecules upregulated in primary breast cancers with high standardized uptake values (SUV) and examine their clinical significance.
Conclusion
High CENP-F expression, correlated with high SUV, was identified as a prognostic indicator of primary breast cancer.
Supporting Evidence
- CENP-F expression was significantly higher in high SUV tumors (74%) compared to low SUV tumors (45%).
- High SUV levels correlated with larger tumor size and higher nuclear grades.
- CENP-F and CDC6 were identified as upregulated in high SUV tumors.
Takeaway
This study found that a protein called CENP-F is more common in aggressive breast cancers, which can help doctors predict how serious the cancer might be.
Methodology
The study compared mRNA expression profiles between tumors with low and high SUVs using cDNA microarray and validated findings with RT-PCR and immunohistochemistry.
Participant Demographics
Patients aged 36 to 81 years, with a mean age of 56 years; included both stage I and stage II breast cancer patients.
Statistical Information
P-Value
0.027 and 0.025
Confidence Interval
HR = 2.94 for CENP-F
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website