Lactate Levels Predict Poor Outcomes in Severe Traumatic Brain Injury
Author Information
Author(s): Sharma Bharti, Jiang Winston, Dhole Yashoda, Agriantonis George, Bhatia Navin D., Shafaee Zahra, Twelker Kate, Whittington Jennifer, Meloni Bruno, Lucke-Wold Brandon
Primary Institution: Elmhurst Hospital Center
Hypothesis
Higher lactate levels would correlate with worse outcomes in patients with severe traumatic brain injury.
Conclusion
Lactate levels can be considered a strong predictor of poor clinical outcomes in patients with severe traumatic brain injury.
Supporting Evidence
- High lactate levels were linked to longer hospital stays and higher mortality rates.
- Significant correlations were found between lactate levels and injury severity scores.
- Male patients had higher lactate levels at hospital admission compared to female patients.
- Lactate levels decreased with increasing age at hospital admission.
- Linear regression models showed a strong positive correlation between injury severity scores and lactate levels.
Takeaway
If a patient has high lactate levels after a serious brain injury, they might have a harder time getting better.
Methodology
This is a level 1 single-center, retrospective study of patients with severe TBI from January 1, 2020, to December 31, 2023.
Potential Biases
Potential confounding variables such as other medical conditions affecting lactate levels were not controlled for.
Limitations
The study is limited to a single center and may not be generalizable to other populations.
Participant Demographics
The study included a diverse population from a major trauma center in New York City.
Statistical Information
P-Value
p = 1.13E−16
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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