Type I collagen gene suppresses tumor growth and invasion of malignant human glioma cells
2007
Type I collagen gene suppresses tumor growth and invasion in glioma cells
Sample size: 4
publication
Evidence: high
Author Information
Author(s): Honma Kimi, Miyata Teruo, Ochiya Takahiro
Primary Institution: National Cancer Center Research Institute, Tokyo, Japan
Hypothesis
The introduction of the human collagen type I α1 (HCOL1A1) gene will suppress the invasion and growth of malignant human glioma cells.
Conclusion
The introduction of HCOL1A1 significantly inhibits tumor growth and invasion in glioma cells, suggesting a potential therapeutic approach.
Supporting Evidence
- Overexpression of HCOL1A1 significantly suppressed the motility and invasion of tumor cells.
- Glioma cell growth was markedly inhibited in vitro and in vivo by the overexpression of HCOL1A1.
- Complete tumor regression was observed in nude mice injected with HCOL1A1-transfected cells.
Takeaway
Scientists found that a special gene can help stop brain cancer cells from growing and spreading.
Methodology
The study involved transfecting the HCOL1A1 gene into T98G glioma cells and assessing their growth, motility, and invasion in vitro and in vivo.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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