Inhaled Corticosteroid Questionnaire for Measuring Side Effects
Author Information
Author(s): Juliet M Foster, Eric van Sonderen, Amanda J Lee, Robbert Sanderman, Antoon Dijkstra, Dirkje S Postma, Thys van der Molen
Primary Institution: University of Aberdeen, UK
Hypothesis
The study aims to assess the construct validity and reliability of the Inhaled Corticosteroid Questionnaire (ICQ) and test its responsiveness to dose changes in adult asthma patients.
Conclusion
The ICQ has good dose-related discriminative properties, is valid, reliable, and shows potential responsiveness to ICS dose change.
Supporting Evidence
- All three construct validity hypotheses were well supported.
- A statistically significant difference existed in scores for 14 domains, with the high ICS dose group scoring highest.
- ICS dose independently predicted ICQ scoring after adjusting for confounders.
- Test-retest reliability was assessed on a randomly selected subgroup of patients.
Takeaway
Researchers created a questionnaire to help asthma patients report side effects from their inhaled medications, and it works well for this purpose.
Methodology
A cross-sectional study where asthma patients completed the ICQ, and a longitudinal study where patients completed the ICQ after changing their ICS dose.
Potential Biases
Self-reported data may introduce bias in the assessment of side effects.
Limitations
The study was observational and had high sample attrition due to deviations from prescribed ICS dose changes.
Participant Demographics
Patients aged 16 to 74 years, with a physician diagnosis of asthma.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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