Ovarian cancer: emerging concept on cancer stem cells
2008
Ovarian Cancer and Cancer Stem Cells
publication
Evidence: moderate
Author Information
Author(s): Ponnusamy Moorthy, Batra Surinder K
Primary Institution: University of Nebraska Medical Center
Hypothesis
The existence of cancer stem cells in ovarian cancer contributes to tumor growth and therapy resistance.
Conclusion
Ovarian cancer stem cells may be responsible for tumor development and contribute to the disease's resistance to conventional therapies.
Supporting Evidence
- Ovarian cancer stem cells can self-renew and differentiate into various tumor types.
- Less than 5% of cancer cells are responsible for the aggressiveness of ovarian cancer.
- Certain markers like CD44, CD117, and CD133 are associated with ovarian cancer stem cells.
Takeaway
Some cells in ovarian cancer can keep growing and make more cancer cells, just like how some special cells in our body can keep making new cells.
Methodology
The review discusses various studies on ovarian cancer stem cells and their characteristics.
Limitations
The review is based on existing studies and may not cover all aspects of ovarian cancer stem cells.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website