Effect of Fluticasone Propionate Nasal Spray on Allergic Rhinitis
Author Information
Author(s): I. M. Garrelds, A. T. de Graaf-in 't Veld, A. P. H. Jansen, R. Gerth van Wijk, F. J. Zijlstra
Primary Institution: Erasmus University Rotterdam; University Hospital Rotterdam-Dijkzigt
Hypothesis
Does fluticasone propionate aqueous nasal spray reduce the release of inflammatory mediators in patients with house dust mite allergy?
Conclusion
Fluticasone propionate aqueous nasal spray reduces the release of inflammatory mediators associated with allergic reactions to house dust mites.
Supporting Evidence
- After allergen provocation, the levels of inflammatory mediators increased in placebo-treated patients.
- Fluticasone propionate treatment tended to decrease the levels of inflammatory mediators.
- Significant correlations were found between the release of mediators and symptom scores.
Takeaway
This study shows that a nasal spray can help people with allergies by reducing the substances that cause their symptoms.
Methodology
A double-blind placebo-controlled crossover study was conducted with nasal challenges and lavages to measure inflammatory mediators.
Limitations
The study was limited to a small sample size and specific patient demographics.
Participant Demographics
24 patients (11 women, 13 men) aged 21 to 50 years with a history of perennial rhinitis and positive skin tests to house dust mite extract.
Statistical Information
P-Value
0.0004; 0.0010; 0.0003; 0.0126; 0.0116
Statistical Significance
p<0.05
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