Complete genome of Phenylobacterium zucineum
Author Information
Author(s): Luo Yingfeng, Xu Xiaoli, Ding Zonghui, Liu Zhen, Zhang Bing, Yan Zhiyu, Sun Jie, Hu Songnian, Hu Xun
Primary Institution: Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, National Ministry of Education, PR China; Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, PR China), the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, PR China
Hypothesis
HLK1T may have pathogenic relevance to humans.
Conclusion
P. zucineum is the first complete bacterial genome in its genus and shows a well-conserved CtrA regulon with C. crescentus.
Supporting Evidence
- P. zucineum maintains a stable association with its host cell without affecting the growth and morphology of the latter.
- The genome consists of a circular chromosome and a circular plasmid, encoding 3,861 putative proteins.
- Comparative genomic analysis revealed that it is phylogenetically closest to Caulobacter crescentus.
Takeaway
Scientists sequenced the entire genome of a new bacterium called P. zucineum, which can live inside human cells without harming them.
Methodology
The genome was sequenced using the whole genome shotgun method and analyzed for gene content and function.
Digital Object Identifier (DOI)
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