Effects of Bee Venom on Glutamate-Induced Toxicity in Neuronal and Glial Cells
2012
Effects of Bee Venom on Glutamate-Induced Toxicity in Neuronal and Glial Cells
publication
Evidence: moderate
Author Information
Author(s): Lee Sang Min, Yang Eun Jin, Choi Sun-Mi, Kim Seon Hwy, Baek Myung Gi, Jiang Jing Hua
Primary Institution: Korea Institute of Oriental Medicine
Hypothesis
Can bee venom prevent glutamate-mediated neurotoxicity?
Conclusion
Bee venom protects against glutamate-induced cell death in neuronal and microglial cells.
Supporting Evidence
- Bee venom significantly inhibited glutamate-mediated toxicity in neuronal cells.
- BV pretreatment altered MAP kinase activation following exposure to glutamate.
- BV increased cell viability compared to untreated cells in the presence of glutamate.
Takeaway
Bee venom can help protect brain cells from damage caused by a chemical called glutamate, which can be harmful in high amounts.
Methodology
The study involved treating neuronal and microglial cells with bee venom before exposing them to glutamate and measuring cell viability and signaling pathways.
Limitations
The study primarily focused on in vitro models, which may not fully represent in vivo conditions.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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