6-Azido-3-O-benzyl-6-deoxy-N,N-diethyl-1,2-O-isopropylidene-d-glycero-α-d-gluco-heptofuranuronamide
2011
Synthesis of a New Compound from Sugar
publication
Evidence: high
Author Information
Author(s): Jenkinson S. F., Oña N., Romero A., Fleet G. W. J., Thompson A. L., Pino-González M. S.
Primary Institution: University of Oxford
Hypothesis
The reaction of a specific sugar derivative with a sulfur ylid will yield a new compound with distinct stereochemistry.
Conclusion
The study successfully synthesized a new compound, confirming its structure through X-ray crystallography.
Supporting Evidence
- The reaction produced an epoxyamide as the only product.
- X-ray crystallography confirmed the structure of the new compound.
- The absolute configuration was determined using D-glucose as the starting material.
- The study involved two distinct molecules in the asymmetric unit.
Takeaway
Scientists mixed a sugar with a special chemical to create a new compound, which they confirmed using X-ray pictures.
Methodology
The compound was synthesized through a reaction involving a sugar derivative and a sulfur ylid, followed by X-ray crystallography for structural confirmation.
Digital Object Identifier (DOI)
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