Cell Wall-Mediated Antifungal Activity of the Aqueous Extract of Hedera helix L. Leaves Against Diplodia corticola
2024

Antifungal Activity of Ivy Extract Against Diplodia corticola

publication 10 minutes Evidence: high

Author Information

Author(s): Crisóstomo Christina, Simões Luara, Barros Lillian, Finimundy Tiane C., Cunha Ana, Oliveira Rui

Primary Institution: University of Minho

Hypothesis

Can the aqueous extract of Hedera helix L. leaves effectively inhibit the growth of Diplodia corticola?

Conclusion

The study found that the aqueous extract of Hedera helix L. leaves significantly inhibits the growth of Diplodia corticola, suggesting its potential as a natural antifungal agent.

Supporting Evidence

  • The extract reduced radial mycelial growth by 70% after 3 days.
  • Chemical analysis identified several antimicrobial compounds in the extract.
  • Mutant strains of Saccharomyces cerevisiae showed increased resistance to the extract, indicating a specific target in the cell wall.

Takeaway

Ivy leaves can help stop a harmful fungus that affects cork oak trees, which is good for the environment and cork production.

Methodology

The antifungal activity was assessed in vitro by measuring the mycelium diameter of Diplodia corticola after exposure to different concentrations of the aqueous extract.

Limitations

The study primarily focuses on in vitro results, which may not fully represent in vivo effectiveness.

Statistical Information

P-Value

p<0.0001

Statistical Significance

p<0.0001

Digital Object Identifier (DOI)

10.3390/antibiotics13121116

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