The Role of Amyloid Precursor Protein in Alzheimer's Disease
Author Information
Author(s): Zheng Hui, Koo Edward H
Primary Institution: Baylor College of Medicine, Houston, TX, USA; University of California, San Diego, La Jolla, CA, USA
Hypothesis
What are the physiological functions of the amyloid precursor protein (APP) in the context of Alzheimer's disease?
Conclusion
The study highlights the complex roles of APP in neuronal function and its potential contributions to Alzheimer's disease pathology.
Supporting Evidence
- APP processing generates beta-amyloid peptides, which are linked to Alzheimer's disease.
- Mutations in APP can cause early-onset familial Alzheimer's disease.
- APP has multiple physiological roles beyond its involvement in amyloid plaque formation.
Takeaway
The amyloid precursor protein is important for brain health, and problems with it may lead to Alzheimer's disease.
Methodology
This review synthesizes findings from biochemical studies, genetic analyses, and animal models to explore the functions of APP.
Limitations
The review primarily focuses on existing literature and may not include all recent findings.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website