Causes of Metabolic Acidosis in Canine Hemorrhagic Shock
Author Information
Author(s): Bruegger Dirk, Kemming Gregor I, Jacob Matthias, Meisner Franz G, Wojtczyk Christoph J, Packert Kristian B, Keipert Peter E, Faithfull N Simon, Habler Oliver P, Becker Bernhard F, Rehm Markus
Primary Institution: Ludwig-Maximilians-University
Hypothesis
The study aims to determine the role of unmeasured anions in metabolic acidosis during hemorrhagic shock in dogs.
Conclusion
Large amounts of unmeasured anions were generated after hemorrhage in this canine model of shock.
Supporting Evidence
- Blood pH decreased significantly from 7.41 to 7.19 during shock induction.
- Transient increases in anion gap and strong ion gap suggested substantial amounts of unmeasured anions were generated.
- Capillary electrophoresis revealed increases in serum concentrations of acetate, citrate, α-ketoglutarate, fumarate, sulfate, and urate after shock induction.
Takeaway
When dogs lose a lot of blood, their bodies make extra acids that aren't usually measured, which can make them very sick.
Methodology
Eleven anesthetized dogs were subjected to hemorrhagic shock, and various blood parameters were measured before, during, and after the shock.
Limitations
The study did not find a strict correlation between strong ion gap and serum concentrations of citrate and acetate, and some metabolites may have been undetectable.
Participant Demographics
Eleven beagle dogs of either gender, weighing approximately 15.7 kg.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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