Effects of 5-Amino-Salicylic Acid and Sulfapyridine on Mycobacterium avium
Author Information
Author(s): Greenstein Robert J., Su Liya, Shahidi Azra, Brown Sheldon T.
Primary Institution: VA Medical Center, Bronx, New York, United States of America
Hypothesis
The mechanism of action of 5-ASA and/or sulfapyridine may be to inhibit MAP growth.
Conclusion
5-ASA inhibits MAP growth in culture, suggesting that the medical profession has been treating MAP infections unknowingly since 1942.
Supporting Evidence
- 5-ASA is inhibitory against MAP in a dose-dependent manner.
- Sulfapyridine has virtually no effect on MAP growth.
- 5-ASA has no effect on M. avium, while sulfapyridine is effective against it.
Takeaway
This study found that a medicine called 5-ASA can stop the growth of a germ that might cause some stomach diseases.
Methodology
The effect on MAP growth kinetics by sulfasalazine and its components were evaluated in bacterial culture using a radiometric detection system.
Limitations
The study's findings need to be replicated in more MAP strains and different inoculation counts.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website