Insulin Levels and Prostate Cancer Risk
Author Information
Author(s): Lehrer S, Diamond E J, Stagger S, Stone N N, Stock R G
Primary Institution: Mount Sinai School of Medicine
Hypothesis
Is there a relationship between serum insulin levels and prostate cancer progression as indicated by disease stage, PSA, and Gleason score?
Conclusion
Higher serum insulin levels are associated with increased risk of advanced prostate cancer stages.
Supporting Evidence
- Increased T stage was independently correlated with increased serum insulin levels.
- Insulin levels of high risk patients were significantly higher than those of medium and low risk patients.
- The positive correlation of log (PSA) and log (insulin) levels was significant.
Takeaway
The study found that men with higher insulin levels are more likely to have more serious prostate cancer.
Methodology
Participants were men with localized prostate cancer, divided into risk groups based on PSA, Gleason score, and T stage, with serum insulin levels measured using a chemoluminescent assay.
Limitations
Insulin levels were measured after therapy, which may affect results, and the intermediate risk group had fewer participants.
Participant Demographics
Participants were men aged 46 to 88, with an average age of 67.
Statistical Information
P-Value
P=0.003
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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