T-lymphocyte Infiltration and Survival in Renal Cancer
Author Information
Author(s): Bromwich E J, McArdle P A, Canna K, McMillan D C, McNicol A-M, Brown M, Aitchison M
Primary Institution: Gartnavel General Hospital, Glasgow
Hypothesis
The study aims to examine the relationship between tumour stage, grade, T-lymphocyte subset infiltration and survival in patients who had undergone potentially curative surgery for renal clear-cell cancer.
Conclusion
Increased intratumoural CD4+ T-lymphocyte infiltrate was associated with poor cancer-specific survival in patients with renal clear-cell cancer.
Supporting Evidence
- Increased CD4+ T-lymphocyte infiltration was associated with poorer cancer-specific survival.
- Patients with higher tumour grades had worse outcomes.
- The study included patients who underwent potentially curative surgery.
Takeaway
The more CD4+ T-lymphocytes found in kidney cancer tumors, the worse the patients did after surgery.
Methodology
Patients with histologically proven renal clear-cell cancer who underwent potentially curative surgery were included, and T-lymphocyte infiltration was assessed using immunohistochemistry.
Potential Biases
Potential observer bias in the assessment of T-lymphocyte infiltration.
Limitations
The study may not generalize to all renal cancer patients as it was conducted in a specific population.
Participant Demographics
The majority of patients were male, with a mix of age groups and stages of renal cancer.
Statistical Information
P-Value
0.005
Confidence Interval
95% CI 1.64–15.52
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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