Electrical Activation in the Coronary Sinus Branches as a Guide to Cardiac Resynchronisation Therapy: Rationale for a Coordinate System Coronary Sinus Mapping in CRT
2011

Mapping Electrical Delays in Cardiac Resynchronization Therapy

Sample size: 13 publication Evidence: moderate

Author Information

Author(s): Scharf Christoph, Krasniqi Nazmi, Hellermann Jens, Rahn Mariette, Sütsch Gabor, Brunckhorst Corinna, Duru Firat

Primary Institution: University Hospital Zurich, Zurich, Switzerland

Hypothesis

Can a coordinate system for coronary sinus mapping improve the predictability of electrical delays during cardiac resynchronization therapy?

Conclusion

Electrical delays within the coronary sinus vary during sinus rhythm but become predictable during right ventricular pacing.

Supporting Evidence

  • Electrical delays in the coronary sinus were found to be inhomogeneous during sinus rhythm.
  • During right ventricular pacing, delays increased significantly, indicating a predictable pattern.
  • A coordinate system was proposed to help define lead positions irrespective of individual coronary sinus branch orientation.

Takeaway

Doctors used a special map to see how electricity moves in the heart during treatment, and they found a way to make it easier to predict where to place the wires.

Methodology

The study involved mapping lead positions in the coronary sinus during sinus rhythm and right ventricular pacing in 13 patients.

Limitations

The study did not assess mechanical dyssynchrony and hemodynamic responses during the implant procedure.

Participant Demographics

All 13 participants were male with a mean age of 67 years.

Statistical Information

P-Value

p<0.0001

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.1371/journal.pone.0019914

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