Trends in Isoniazid Resistant Tuberculosis from 1994 to 2009
Author Information
Author(s): Helen E. Jenkins, Matteo Zignol, Ted Cohen, Adithya Cattamanchi
Primary Institution: Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Hypothesis
How has the burden of isoniazid resistant tuberculosis changed globally from 1994 to 2009?
Conclusion
Outside Eastern Europe, about one in seven incident TB cases has isoniazid resistance, while this rises to nearly half within Eastern Europe.
Supporting Evidence
- 44.9% of incident TB cases in Eastern Europe had isoniazid resistance.
- 13.9% of incident TB cases in all other regions combined had isoniazid resistance.
- 40% of high HIV prevalence countries reported national data on isoniazid resistance.
Takeaway
This study looked at how many people have a type of tuberculosis that doesn't respond to a common medicine called isoniazid, and found that it's a big problem in some places, especially in Eastern Europe.
Methodology
Data from the World Health Organization on isoniazid resistant tuberculosis cases reported from 1994 to 2009 were analyzed to estimate the burden and trends.
Potential Biases
Potential underreporting of cases in regions with less surveillance.
Limitations
Many countries provided data only at a single time point or sub-nationally, limiting trend analysis.
Participant Demographics
Data included reports from 131 settings, covering 56% of the world's population.
Statistical Information
P-Value
0.1
Confidence Interval
95% CI: 34.0%, 55.8%
Statistical Significance
p<0.1
Digital Object Identifier (DOI)
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